The special regions of Mars are regions where it's thought there's a possibility of habitats where Earth life could be able to survive. This includes the black asterisks on this map. So humans on the surface couldn't land in any of those regions - everyone agrees on that - for planetary protection reasons. But then - what about a hard landing if the spacecraft misfires its motors, for instance - a crash?
And anyway Mars is one connected planet with global dust storms and wind patterns - can you guarantee contamination by Earth life that will stay in one part of Mars, again especially after a crash? It would be a risky mission, especially for humans, and if you had, say, a half dozen missions without a crash, still, it doesn't prove much. The next one could be the first one to crash - often happens with early versions of vehicles, test flights etc. The landing on Mars is likely to be one of the most risky points in the journey. Even without a crash, you can't land an "inside out biocontainment laboratory" on Mars with humans on the inside of it.
The only way this can be consistent with planetary protection is through relying entirely on hostility of the surface of Mars to protect the planet. But that's not certain, that you can do this.