Okay - there are a few really large interesting numbers - at least - interesting in the sense that they were used in a proof and have been given names - so largest named numbers:
For a while, Skewe's number was the record holder 10^(10^(10^963)) - an early upper bound for another number now known to be somewhere between 10^14 and 10^317. Skewes' number, also Skewes' Numbers - Large Numbers
Then there's Graham's number, too large to notate using powers (even e.g. a power tower with as many numbers in it as there are particles in the known observable universe would be far too small).
Again - the interesting thing is - used in a proof as an upper bound - though the number it's an upper bound for is believed to be quite small. The lower bound is 13.
Those though are just upper bounce, not especially interesting in their own right, more interesting, because used in proofs of other things.
It's very easy to make far larger numbers than these. But these I think are good candidates for "meaningful" because used in famous proofs and because they have been given names.
As for numbers interesting in their own right, perhaps the Mersenne primes are largest?
These are the largest known prime numbers. See Mersenne prime
Largest currently I think is M57885161 which has 17,425,170 digits in decimal notation